HIRAX 750 IU – Liquid Hyaluronidase for HA Filler Dissolution & Edema Management

HIRAX 750 IU is a sterile liquid hyaluronidase injection manufactured by BMI Korea. It contains 750 IU of hyaluronidase in 0.5 mL and is used to increase tissue permeability, enhance dispersion of injected medications, promote reabsorption of excess fluids, and dissolve unwanted or misplaced hyaluronic acid (HA) fillers.

In aesthetic medicine, HIRAX is widely used as a filler reversal agent because hyaluronidase breaks down hyaluronic acid, allowing practitioners to correct overfilled areas, asymmetry, nodules, vascular compromise, or other HA filler-related complications.

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Key Benefits

• Dissolves hyaluronic acid fillers
• Corrects filler overcorrection and asymmetry
• Helps manage HA filler complications
• Enhances diffusion of injected medications
• Promotes reabsorption of excess tissue fluids
• May help reduce edema and swelling
• Ready-to-use liquid formulation
• No reconstitution required
• Available in multiple strengths including 300, 750, 1500, 2000, and 5000 IU versions.

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Product Specifications

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Mechanism of Action

Hyaluronic Acid Breakdown

Hyaluronidase is an enzyme that hydrolyzes hyaluronic acid found within connective tissues. By breaking down HA, it temporarily increases tissue permeability and accelerates the dispersion and absorption of injected substances.

Filler Dissolution

When injected into areas containing HA filler, hyaluronidase breaks down the filler gel, allowing the body to naturally remove the degraded material over time. This makes it the standard reversal treatment for hyaluronic acid fillers.

Edema Reduction

HIRAX may also promote reabsorption of excess fluid and blood within tissues, which is why hyaluronidase has medical applications in edema management and improving drug diffusion.

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Common Aesthetic Uses

• Dissolving unwanted HA fillers
• Correction of filler migration
• Treatment of filler nodules
• Management of overfilled lips
• Correction of facial asymmetry
• Emergency management of vascular occlusion caused by HA fillers
• Adjustment of cheek, chin, jawline, tear trough, and nasolabial fillers

HIRAX does not dissolve collagen stimulators such as PLLA, PDLLA, CaHA, or PCL products. Hyaluronidase works specifically on hyaluronic acid-based fillers.

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Available Strengths

HIRAX is manufactured in several concentrations:

• 300 IU
• 750 IU
• 1500 IU
• 2000 IU
• 5000 IU

This allows practitioners to select an appropriate dose according to the clinical situation.

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Advantages of the Liquid Formulation

Compared with traditional lyophilized (powder) hyaluronidase:

• Ready for immediate use
• No dilution required
• Consistent concentration
• Reduced preparation time
• Lower risk of reconstitution errors

HIRAX is marketed as a highly purified liquid hyaluronidase formulation.

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Storage

• Refrigerated storage: 2–8°C
• Protect from light
• Avoid freezing
• Follow manufacturer handling recommendations.

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Safety Information

Potential side effects may include:

• Injection-site redness
• Swelling
• Tenderness
• Allergic reactions
• Local irritation

Because hyaluronidase can affect naturally occurring hyaluronic acid within tissues, treatment should only be performed by trained medical professionals.

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Comparison with Other Dissolving Agents

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Ideal Clinical Use

HIRAX 750 IU is often chosen when practitioners need:

• Moderate-strength HA filler correction
• Lip filler adjustment
• Tear trough filler correction
• Small-volume facial filler reversal
• Controlled hyaluronidase dosing

Higher-strength versions may be preferred for larger treatment areas or emergency vascular compromise protocols.

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Important Notice

HIRAX 750 IU is a prescription medical product intended for use by licensed healthcare professionals trained in injectable aesthetics, emergency filler complication management, and hyaluronidase administration.